Glomerular endothelial NOS (eNOS) expression in type 2 diabetic patients with nephropathy.
نویسندگان
چکیده
3. Li Volti G, Sorrenti V, Murabito P et al. Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemiareperfusion injury. Transplant Proc 2007; 39: 2986–2991 4. Datta PK, Koukouritaki SB, Hopp KA et al. Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. J Am Soc Nephrol 1999; 10: 2540–2550 5. Ahmad M, Turkseven S, Mingone CJ et al. Heme oxygenase-1 gene expression increases vascular relaxation and deceases inducible nitric oxide synthase in diabetic rats. Cell Mol Biol 2005; 51: 371–376 6. Katavetin P, Inagi R, Miyata T et al. Erythropoietin induces hemeoxygenase-1 expression and attenuates oxidative stress. Biochem Biophys Res Commun 2006; 359: 928–934 7. Calò LA, Stanic L, Davis PA et al. Effect of epoetin on HO-1 mRNA level and plasma antioxidants in hemodialysis patients. Int J Clin Pharmacol Ther 2003; 41: 187–192
منابع مشابه
Association of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
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Our recent publication showed that pharmacological blockade of arginases confers kidney protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS)3-dependent mechanism. Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine. Lack of L-arginine results in reduced NO production and eNOS uncoupling, which lead to endothelial dysfunction. Therefore, we hypo...
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BACKGROUND Diabetic nephropathy (DN) is a chronic microangiopathic complication of type 2 diabetes mellitus (DM).Vascular endothelial dysfunction resulting from impaired nitric oxide synthase (NOS) activity in the vascular endothelial cells has been suggested as playing an important role in the pathogenesis of diabetic nephropathy (DN). Endothelial nitric oxide synthase (E-NOS) gene G894T polym...
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ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 23 9 شماره
صفحات -
تاریخ انتشار 2008